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Furthermore, the expression level of METTL3 in aortic tissues of TAAD patients was significantly higher than that in non-AD subjects, and METTL3 promoted the degradation of the mRNAs of SLC7A11 and FSP1 to inhibit their protein expression in primary cultured human aorta SMCs (HASMCs)

It also lowers blood cholesterol and homocysteine levels

Nature communications , 11 (1), 5205

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Those forces are temperature-sensitive