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Some studies report observable changes within a few weeks, while others may require a longer duration of 4-6 weeks or more to gather substantial data

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Alcohol & stress: Limit alcohol (its metabolism consumes NAD+) and manage stress, since chronic stress activates PARPs that deplete NAD+ pools

Evidence GHK-Cu is associated with regulation across more than 4,000 genes, including collagen synthesis, antioxidant defense, wound healing, inflammation, and tissue breakdown

GHK-Cus ability to remodel scar tissue through its balanced MMP regulation (breaking down disorganized collagen in scars while promoting new, organized collagen formation) makes it particularly relevant for improving the appearance of stretch marks alongside loose skin