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Correct Relevant Nutrient Deficiencies Vitamin B6, B12, folate, riboflavin, choline, betaine, magnesium, zinc, selenium, glycine and cysteine availability may influence methylation, antioxidant protection and sulfur metabolism

Gastroenterology 135 , 1591-1600 e1591 (2008)

doi: 10.2147/ijn.s273713 Summary Keywords immunosuppression, immunotherapy resistance, nanomedicine delivery systems, osteosarcoma, translational oncology, tumor microenvironment (TME) Citation Huang Q, Yu G, Shi B and Deng T (2026) Engineering immunity in osteosarcoma: nanomedicine strategies for overcoming immune evasion

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When the researchers compared the three groups, they found that the enterocytes (intestinal cells) of the non-berberine HFD group secreted significantly less GLP-1 than the healthy controls

Selenium: A cofactor for glutathione peroxidases, supporting antioxidant defenses