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Insulin resistance disrupts key signaling pathways essential for muscle protein synthesis, particularly the IGF1PI3KAktmTOR axis [48, 53], leading to reduced protein synthesis, increased protein breakdown and consequent loss of muscle mass

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IGF-1 LR3 also has reduced binding affinity for IGF-binding proteins (IGFBPs), which normally sequester IGF-1 in circulation and limit its bioavailability

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Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia

Overweight and obesity management Medicine options for weight management in adults (NG246)