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The peptide demonstrates dual-phase mechanisms: acute phase preservation of ischemic tissue through anti-apoptotic signaling via Akt activation, and chronic phase activation of cardiac progenitor cells (c-kit+ populations) that contribute to myocardial repair through both structural replacement and paracrine support, with studies showing 200% increases in progenitor cell mobilization and cardiac homing

10.3389/fphar.2022.995512 62 DuX

Long-term safety studies (beyond 6 months) do not appear to have been conducted for oral glutathione [1]

doi: 10.1042/bsr20191900 252 WanLLiuJHuangCZhaoLJiangHLiuLet al

Improvement of antioxidant status after Brazil nut intake in hypertensive and dyslipidemic subjects