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Food and Drug Administration PubMed PubMed No published multi year surveillance exists for adverse events, and current absence of large documented harm does not imply safety equivalence to approved therapeutics with rigorous post marketing data

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My over active imagination is conjuring up pictures of anaphylactic shocks, even though I have had the B12 injections from doctor before

Oral Dosing Runs Higher Injectable: 200 to 500mcg per dose Oral: 500 to 1,000mcg per dose, once or twice daily, taken on an empty stomach Higher oral doses are used to make up for the fact that the gut absorbs the compound poorly compared to injections

In a physical dependence assay (assessed at 6, 14, 42, and 72 hours after the conditioning treatment) shorter pre-convulsive latencies were noted in diazepam conditioned mice than in non-conditioned healthy mice following an isoniazid treatment forty-two and seventy-two hours after the conditioning treatment