glp 1 mash GLP-1 receptor agonists improve mostly via extrahepatic actions: 1️⃣ CNS appetite control → weight loss → ↓ systemic inflammation 2️⃣ ↓ Chylomicron synthesis & improve lipid metabolism 3️⃣ Bind… How to Use a GLP-1

Although no paresis of the upper extremities was present, he still suffered from exertional weakness

doi: 10.3389/fphar.2021.632295 Received 07 December 2020 Accepted 13 April 2021 Published 10 June 2021 Volume 12 - 2021 Edited by Chiara Bianca Maria Platania, University of Catania, Italy Reviewed by Doreen Schmidl, Medical University of Vienna, Austria Francesca Lazzara, University of Catania, Italy Updates Copyright 2021 Zlatar, Kokot, Vuletic, Masnec, Kralj, Perisa, Barisic, Radic, Milanovic, Drmic, Seiwerth and Sikiric

A high toxic burden : Our bodies are designed to process and eliminate any toxins we come into contact with through our natural detoxification pathways

When GLP-1 is secreted from L-cells through the TGR5 agonist, it stimulates GLP-1R in enterochromaffin cells and induces serotonin or 5-hydroxytryptamine (5-HT) secretion from these cells

They observed, however, that this only happened in 'the presence of supra-fasting blood glucose levels or well fed individuals'

Lancet 387, 661670