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By performing a genome-wide activation screen, they discovered a group of genes antagonize ferroptosis, including guanosine triphosphate (GTP) cyclohydrolase-1 (GCH1) and its metabolic derivatives BH4/BH2
Berberine and its clinical application for the treatment of metabolic disorders: An update
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Nutr J 12:37
These findings remain preclinical , meaning they have largely been observed in laboratory and animal studies rather than human clinical trials
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