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In STEP 1 (NEJM 2021), FDA-approved semaglutide 2.4 mg with lifestyle support produced a mean 14.9% body weight reduction at 68 weeks versus 2.4% with placebo
A tri-agonist
Both medications share similar goals
Non-alcoholic fatty liver disease risk with GLP-1 receptor agonists and SGLT-2 inhibitors in type 2 diabetes: a nationwide nested case-control study
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Addison disease and Peutz-Jeghers syndrome also appear in perioral and oral locations as pigmented macules
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