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confirmed that TFAP2C regulated GPx1 expression by directly binding to the GPx1 promoter, which contains an AP-2 regulatory region, and the methylation of the CpG island in the GPx1 promoter region prevented the binding of TFAP2C by encompassing the AP-2 regulatory region [81]

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The switching study: ATTAIN-MAINTAIN results Perhaps the most important piece of evidence for understanding how orforglipron and tirzepatide relate to each other is not a head-to-head competition

1,2 The authors of the review in Biomolecules suggest that larger sample sizes and longer-term studies may help gather clearer results

doi: 10.1016/j.molimm.2017.01.009 78 WangXPanLNiuDZhouJShenMZengZet al