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To ensure cell penetration of the synthesized PROTACs, we performed NanoBRET TM (Bioluminescence Resonance Energy Transfer) assays ( Figure 2B )

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Chronic heavy alcohol consumption can lead to alcoholic cardiomyopathy, characterized by left ventricular dilation, reduced myocardial contractility, and myocardial fibrosis, ultimately resulting in heart failure and arrhythmias [53]