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Key Points Small bowel obstruction is commonly caused by adhesions or hernia, and large bowel obstruction is commonly caused by malignancy or diverticular disease The cardinal features for bowel obstruction are abdominal pain, vomiting, abdominal distension, and absolute constipation Early recognition of those patients with impending strangulation and ischaemia is essential, as urgent surgery will be required in such cases The majority of cases of adhesional bowel obstruction can be managed with a drip and suck approach Large bowel obstruction more often require endoscopic or surgical intervention

The extended coverage program, CMS confirmed, will extend through December 31, 2027

Individuals with a history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) are contraindicated due to mechanistic overlap with GLP-1 agonists

Constant exposure can downregulate these receptors, requiring higher doses for the same effect

If youve tried certain medications before without success, it may be worth revisiting them with your provider to explore whether they could now be a better fit

What you need to know: When glutathione neutralizes free radicals, it changes