(8) sa Westrin, Rolf Ekman, and Lil Trskman-Bendz (1998) High delta sleep-inducing peptide-like immunoreactivity in plasma in suicidal patients with major depressive disorder Biological Psychiatry, Volume 43, Issue 10, 15 May 1998, Pages 734-739
You might notice brighter, more even skin within 4-6 weeks of consistent vitamin C use
What we know about extended use The longest controlled human trials ran for 12 weeks
Real-time imaging of the intracellular glutathione redox potential
However, for individuals actively managing complex, reactive chronic illnesses like Long COVID, ME/CFS, or severe dysautonomia, such high starting doses are rarely recommended due to the high potential for gastrointestinal upset or rapid, uncomfortable detoxification reactions (often referred to as a Herxheimer reaction)
Full improvement can take 6-12 months as hair follicles complete their growth cycles