GH/IGF-1 axis modulation Several Sikiric studies (2010-2020) reported indirect modulation of the GH-IGF-1 axis by BPC-157, with moderate induction of GH receptor expression in scar tissue
The approach to TRT itself is a phased process and can be nuanced
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The proposed mechanism involves preventing GABA receptor downregulation, counteracting compensatory NMDA receptor sensitization, and stabilizing benzodiazepine receptor configuration
The position this article takes, given those three valid critiques, is that the mechanism evidence is strong enough, the delivery evidence is biologically plausible enough, and the safety window is wide enough that the recommendation is defensible
The peptides on the agenda: BPC-157, KPV, TB-500, MOTs-C, Emideltide (the FDA's name for delta sleep-inducing peptide, DSIP), Semax, and Epitalon