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In Alzheimer's and Parkinson's diseases, pathological changes such as amyloid- accumulation or loss of dopaminergic neurons can disrupt normal homosynaptic long-term potentiation, contributing to cognitive or motor deficits

DSIP Clinical Research Overview DSIP & Sleep A small clinical study tested Delta Sleep-Inducing Peptide (DSIP) in patients with severe insomnia to see if it could help improve their sleep and daytime well-being

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However, during an initial loading phase, a more frequent schedule may be necessary

5-Amino-1MQ is a selective inhibitor of the NNMT enzyme