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The Phase 2 trial (Jastreboff et al., NEJM 2023) identified gastrointestinal effects as the most common adverse events

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Glucagon-like peptide-1 (GLP-1) inhibits advanced glycation end product (AGE)-induced up-regulation of VCAM-1 mRNA levels in endothelial cells by suppressing AGE receptor (RAGE) expression

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2019;68(suppl 1):985-P

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