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Blood glucose levels must be maintained at all times to avoid hypoglycemia and to supply the brain with its preferential fuel

Several events seen in the brain of neurodegenerative diseases could give rise to an abnormal production of reactive oxygen spices (ROS)

Thus, NRF2 promotes the expression of enzymes that synthesize UDP-glucuronate, as well as glucose uptake to promote entry of G6P into this pathway

Twenty key molecular drivers involved in proteolysis and angiogenesis have been identified as potential biomarkers and therapeutic targets

Minimizing dosages of such medications or finding appropriate alternatives can help prevent onset of the disease

10.1038/emboj.2009.86 15 ChenS.ZhaoY.WangY.ShekharM.TajkhorshidE.GouauxE