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Cell transfection The shVRK2-expressing and VRK2-overexpressing plasmids were purchased from Genechem (Shanghai, China) and then used for constitutive expression of shRNA or cDNAs

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Protocol Timeline See what to expect, week by week Protocol Timeline See what to expect, week by week Your protocol timeline What to expect, week by week Weeks 1-2 Nightly dosing before bed on an empty stomach