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Emerging Role of GLP-1 Agonists in Obesity: A Comprehensive Review of Randomised Controlled Trials (June 2023) Insufficient Sleep Predicts Poor Weight Loss Maintenance After 1 Year (May 2023) Stress and Obesity (January 2019) Once-Weekly Semaglutide in Adults With Overweight or Obesity (March 2021) The Effect of Semaglutide 2.4 mg Once Weekly on Energy Intake, Appetite, Control of Eating, and Gastric Emptying in Adults With Obesity (March 2021) Efficacy and Safety of Semaglutide for Weight Management: Evidence From the STEP Program (April 2022)

If late-stage secondary patents are now economically less valuable for small molecules, IP teams should concentrate prosecution resources on broader, earlier-stage patents that can be used to capture more commercial value during the pre-negotiation window, rather than filing dense thickets of late-stage formulation and method-of-use patents that will be economically devalued by the IRA clock

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