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Available data are insufficient to inform recommendations to mitigate the risk of pulmonary aspiration during general anesthesia or deep sedation in patients taking ZEPBOUND, including whether modifying preoperative fasting recommendations or temporarily discontinuing ZEPBOUND could reduce the incidence of retained gastric contents

These can be from minor to serious side effects

However, GLP-1 agonists have limitations

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Some individuals are more prone to a B12 deficiency than others