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2020 De Flora S et col Rationale for the use of N-acetylcysteine in both prevention and adjuvant therapy of COVID-19

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To date, more than 100 natural medicine monomers have been reported to activate the GSH system by several mechanisms to protect the heart from oxidative stress

It is not surprising then that most attempts to increase intracellular glutathione (GSH) by glutathione supplementation have been unsuccessful [19, 20]

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