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You should contact your GP or healthcare provider if you experience: Severe or persistent gastrointestinal symptoms that don't improve after the first few weeks, particularly if they're affecting your nutrition or hydration Signs of pancreatitis severe abdominal pain that may radiate to your back, often accompanied by nausea and vomiting Symptoms of hypoglycaemia shakiness, sweating, confusion, rapid heartbeat, or extreme hunger, especially if you're taking other diabetes medications Persistent vomiting or diarrhoea that could lead to dehydration and kidney problems Changes in vision or eye problems, as rapid improvement in blood glucose can temporarily worsen diabetic retinopathy Symptoms of thyroid problems a lump or swelling in your neck, hoarseness, difficulty swallowing, or shortness of breath (thyroid tumours have been observed in animal studies, though the relevance to humans is unknown) Signs of gallbladder problems pain in the upper right abdomen, fever, yellowing of skin or eyes Allergic reactions rash, itching, swelling, or difficulty breathing Routine follow-up appointments are important to monitor your HbA1c levels (a measure of long-term blood glucose control), assess weight changes, and review your overall diabetes management plan

Patients showing changes in mood and behavior, indicating depression or suicidal thoughts with a history of active suicide ideation may be advised to stop semaglutide

To confirm that CVOTs findings are consistent in more diverse populations reflective of patients in the clinical practice, we may need to look beyond clinical trials to real-world evidence studies

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Mielgo-Ayuso et al