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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
Active or recent pancreatitis contraindicates use
Key Takeaways 5-Amino-1MQ inhibits nicotinamide N-methyltransferase (NNMT), increasing cellular NAD+ levels by preserving nicotinamide for NAD+ salvage pathways rather than methylation to N-methyl nicotinamide
These studies only show a link between vitamin B12 deficiencies and weight gain, Matthew Cowling, D.O., a physical medicine and rehabilitation specialist in Madison, Wisconsin who specializes in weight loss, previously told The Edge
At-risk groups should undergo regular blood tests to ensure their B12 levels remain within a healthy range
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