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Consensus estimates see the market for oral formulations stabilizing at about 30%. Limited head-to-head data comparing newer oral therapy to injections have shown similar safety and efficacy

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1 In clinical trials, participants showed a slight early weight reduction during the 2.5mg starter phase

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The SURMOUNT-5 clinical trial published in The New England Journal of Medicine showed that Zepbound (tirzepatide) achieved an average weight loss of 20.2% compared to 13.7% with Wegovy (semaglutide) at 72 weeks

Key molecular properties used for mapping include molecular weight, lipophilicity (logP and logD), topological polar surface area (TPSA), and hydrogen-bond dynamics