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Moving from left to right along the X-axis of the energy diagram, the orientation of the linear chain changes from an extended form aligned parallel to the membrane surface to one where the folding of the linear chain allows it to position itself perpendicularly to the surface, as observed in the sampled conformations

Key antibodies used included: anti-FOXO4 (two different clones, ab128908 and sc-373877), anti-StAR, anti-CYP11A1, anti-3-HSD, and anti-Ser15-phospho-p53

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Split dosing Instead of one weekly injection, some researchers split their dose across two injections per week

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