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Metformin, a widely used antidiabetics entering cells through the thiamine transporters, is known to reduce intestinal thiamine content in mice (96)

Vitamin B12 helps reduce the gastrointestinal side effects commonly associated with initiating GLP-1/GIP therapy, including nausea

doi: 10.3390/cells8090953 178 WangJYanSLuHWangSXuD

Nature 554, 475480

A 5-day dosing interval has not been studied in any retatrutide clinical trial

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