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The complete absence of human safety data for neurological applications, particularly long-term use affecting mental health, represents a critical knowledge gap

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Technical barrier of ferroptosis marker detection Apoptosis, pyroptosis, and autophagy involve hallmark molecules that can execute the cell death program, enabling researchers to detect these PCDs by simple but specific techniques (Luchetti et al., 2023)

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Direct intravenous administration of these ferroptosis inducers of small molecules may lead new damage to normal cells and deteriorate the side effects of the current anti-tumor drugs