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Melanin synthesis is rate-limited by tyrosinase enzyme activity and melanosome maturation

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Under normal physiological conditions, cellular H 2 O 2 levels are maintained within homeostatic limits through a network of antioxidant defense systems

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Differential expression analysis of transcriptomes from WT and SQLE -KO cells infected by Cryptosporidium revealed an upregulation of host cholesterol biosynthesis genes in SQLE -KO cells compared to WT (Fig 3B)

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