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Ipamorelin activates the Gq-coupled calcium signaling pathway in somatotrophs, while GHRH analogs (like CJC-1295) activate the Gs-coupled cAMP pathway

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These multifaceted roles of central GLP-1R activation may provide a plausible biological framework for understanding the spectrum of reported NAEs associated with GLP-1 RAs

Ottestad I, Vogt G, Retterstol K, Myhrstad MC, Haugen JE, Nilsson A et al

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