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In the US, the adult obesity rate is far higher than the global average, at 43%, with an incalculable impact on the nations health, quality of life, and economic wellbeing
On one hand, ROS-mediated damage to the cystine-glutamate antiporter SLC7A11expressed on RMECs, RPE cells, and Mller cellsimpairs cystine-cysteine biotransformation, disrupts the GSH- GPX4 antioxidant axis, and thereby triggers ferroptosis in these cell populations
Matsui H et al
REDD1 is a gatekeeper of murine hematopoietic stem cell functions during stress responses
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