The following describes what the literature discusses not a clinical recommendation of any kind
Although the exact causes of said decrements in NO production with aging have not been fully elucidated, evidence implicates decreased availability of cofactors necessary for NO production, such as tetrahydrobiopterin (BH4), decreased expression and activity of eNOS, decreased availability of L-arginine (via increased arginase activity), and excessive superoxide production as potential culprits (Cau et al., 2012
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Vilibi M, Juki V, Vidovi A, Breci P
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Vitamin B12 can be converted to coenzyme B12 in tissues