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However, from a practical standpoint, the immediate reduction of appetite is not a universal experience
What the data shows: REDEFINE-1 (obesity without diabetes): 22.7% average weight loss vs 2.3% placebo | 91.9% achieved 5% weight loss REDEFINE-2 (type 2 diabetes + obesity): 14-16% weight loss sustained over 68 weeks Consistent GLP-1 class safety profile with potential for fewer GI side effects due to amylin co-agonism What this means for practice: This isn't just another weight-loss drugit's addressing the mechanistic gap in dual-pathway therapy
All this information will help them determine the most suitable course of medication management
While the exact mechanisms remain to be fully elucidated, proposed pathways include modulation of dopamine release, suppression of neuroinflammation, and attenuation of stress-related neural circuits (27)
The substantial barriers to access to GLP-1s reflect existing inequities and poor alignment of incentives in our healthcare system, says study coauthor Katherine Hempstead, senior policy officer at the Robert Wood Johnson Foundation
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