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In parallel, glycine, another major component of collagen, is synthesized from serine, which is derived from the glycolytic intermediate 3-phosphoglycerate via the enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH), and subsequently converted by serine hydroxymethyltransferase 1/2 (SHMT1/2) [17, 18]

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Additionally, consuming a plant-based diet containing soy, legumes, and quinoa, dietary supplements rich in omega-3 and fermented foods significantly decreases TMAO levels, according to other studies [77, 82]