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Nevertheless, GLP-1 presented a rather ephemeral circulatory half-life, lasting a mere 12 min, due to the rapid enzymatic degradation by dipeptidyl peptidase IV (DPP-4), which markedly limits its biological efficacy [3,4,5]
Those observations describe monitored trial participants under a defined study design
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It belongs to the class of GLP-1 receptor agonists, which mimic the natural incretin hormone responsible for regulating blood sugar and appetite. This dual-action effect allows semaglutide to simultaneously improve glycaemic control and promote weight losstwo outcomes that are closely interconnected in metabolic health
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