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Polak G, Rola R, Gogacz M, Kozio-Montewka M, Kotarski J

(2023) 39:e3596

REDEFINE-4 showed 23.0% weight loss at 84 weeks head-to-head against tirzepatide (Zepbound), which produced 25.5%

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So, while there might be a very brief, temporary increase in heart rate post-administration, the long-term downstream effects of the resulting GH pulse can be profoundly beneficial for the cardiovascular system