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Forlenza OV, Diniz BS, Teixeira AL, Ojopi EB, Talib LL, Mendonca VA, et al

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326 Astrocytes regulate glutamate presence in the interstitium, 327 tune neuronal excitability through K + buffering, 328 and influence inhibitory/excitatory balance through tonic release of GABA 329 and by supplying Cl - to inhibitory synapses

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Full therapeutic benefit typically becomes evident within three to six months, with many patients experiencing sustained pain relief that persists long after the treatment course ends

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