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In patients with alcohol dependence and delirium unresponsive to high doses of benzodiazepines, alcoholic pellagra should be considered, since chronic alcoholism leads to a lack of tryptophan 2,3-dioxygenase, an enzyme linked to niacin synthesis
Patients with longstanding IBS-like symptoms that have never been thoroughly investigated are also frequently found to have SIBO as an underlying driver.
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In a mass-balance study of 14C-futibatinib, the major circulating metabolite was a cysteinylglycine conjugate (~13% CRA), and hepatocyte studies showed additional GSH, cysteine, glucuronide, and sulfate metabolites
