With regard to glutamine metabolism, inhibition of glutamine utilization has likewise been incorporated into the clinical development strategy of metabolic targeting plus immunotherapy. Animal studies have shown that JHU083, a prodrug of the glutamine antagonist 6-diazo-5-oxo-L-norleucine (DON), not only suppresses tumor growth, but also reshapes the transcriptional profile and antigen-presentation/inflammatory cytokine characteristics of tumor-associated macrophages, shifting them from an immunosuppressive tendency toward a functional state more favorable for antitumor immunity (118)
Targeted mobilization of Lrig1(+) gastric epithelial stem cell populations by a carcinogenic helicobacter pylori type iv secretion system
Emerging economies in Asia, Latin America, and the Middle East are experiencing rapid growth in health and beauty sectors, driven by rising middle classes and urbanization
Such a redox environment may provide a basis for ROS-dependent signaling pathways to subsequently drive progressive phenotypes such as proliferation, survival, and angiogenesis ( Figure 2 Within the tumor microenvironment, hormonal signaling serves as a critical upstream trigger that drives HGSOC progression through ROS-dependent pathways
pmid:12666096
& Pili, R