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Luzzi V, Mazur M, Guaragna M, et al

The combination yields greater weight loss than either agent alone, with mean reductions in body weight of approximately 20.4% over 68 weeks in non-diabetic adults and 13.7% in those with type 2 diabetesfar exceeding placebo and monotherapy arms

In FRDA, the expression of the encoded protein frataxin was decreased, leading to obstruction of mitochondrial matrix ironsulfur cluster biosynthesis, mitochondrial dysfunction, and mitochondrial iron accumulation, and finally result in increased oxidative stress

Vitamin C helps to inhibit the enzyme tyrosinase, which helps to prevent melanin production