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(2024) BPC-157 as cytoprotection mediator with neurotransmitter-like activity Pharmaceuticals Sikiric et al
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More serousB12 deficiencies have the potential to impair heart and neurological function, leading to a wide range of serous symptoms, including but not limited to tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia, and changes in reflexes
To determine the solution structural model of the p53 TAD2 -FOXO4-DRI complex using NMR spectroscopy, we recorded several sets of NMR experiments on two types of complexes: 13 C, 15 N-labelled p53 TAD2 -FOXO4-DRI and 13 C, 15 N-labelled FOXO4-LRI D -p53 TAD2 (see methods)
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Pickart and Margolina's review provides the broader gene expression context for why these effects occur
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