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Do you have a genetic defect in the MTHFR gene

I work closely with my healthcare provider, get regular lab work, and carefully document all effects

Sensitivity analyses were performed to assess the impact of the definition of MACE (three-point MACE [non-fatal myocardial infarction, non-fatal stroke and cardiovascular death] vs other MACE definitions), risk of bias, data source (electronic healthcare records vs other data sources) and method of adjusting for confounding (propensity scores or inverse probability of treatment weighting vs multivariable regression, restriction or matching)

We all have biases, the only way were going to get beyond them is to embrace the counter intuitive and check ourselves constantly with data

Beyond a certain threshold, higher doses don't produce additional benefits and may actually reduce effectiveness through receptor desensitization