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The Endocrinology review notes that tirzepatide, which acts on both GLP-1 and GIP receptors, is associated in trials with fewer discontinuations from gastrointestinal events than semaglutide, and proposes that part of the explanation lies in GIP-receptor neurons in the area postrema damping the nausea circuits

H2 receptor antagonists also affect B12 absorption, but less than PPIs

It dramatically increases the risk of severe nausea, vomiting, and other GI side effects without improving efficacy