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It is not a weight-loss drug

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Following the rate determining formation of 8-enolate , this intermediate shows only marginal stabilization over the corresponding transition state and evolves to 8-B4 in a barrierless step

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Patients experiencing severe nausea, vomiting, abdominal distension, or known gastroparesis before surgery may require individualized anesthesia planning, delayed procedures, modified fasting instructions, or additional airway precautions to reduce aspiration risk