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L-Carnitine synthesis occurs mainly in the liver and kidneys, but it is also transported to other tissues, especially the muscles and heart, where it is needed most as much as 95% of our L-Carnitine reserves are located in the muscles

"I would encourage folks to really have careful conversations with their physician, make a shared decision about whether to start the GLP-1s, and then to really monitor it

Because oral L-carnitine is only about 15% absorbed, the unabsorbed remainder passes into the lower gut, which is part of why higher oral doses drive more GI complaints

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In obesity care, the benefits are framed more broadly, encompassing improvements in mobility, sleep, metabolic health, and overall well-being

Malmlf, P