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Severe gastrointestinal adverse reactions may lead to dehydration and acute kidney injury, particularly in patients with pre-existing renal impairment, requiring close monitoring of fluid status and kidney function

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Exp Clin Endocrinol Diabetes 122(10):608614 Younce CW, Burmeister MA, Ayala JE (2013) Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a