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Weight loss at 80 weeks (primary endpoint): 45.3% of participants achieved 30% or greater weight loss at 80 weeks a threshold historically associated with bariatric surgery

Research published in the Journal of Clinical Biochemistry found that methionine supplementation increased hepatic SAMe concentrations by 4060% within 48 hours, correlating with improved fatty acid oxidation rates in subjects under caloric restriction

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(PMID: 15068981) Intravenous vitamin injections: where is the evidence