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Current scientific consensus emphasizes that the primary criterion for probiotic selection is the specific clinical indicationwhether prophylactic, therapeutic, or adjunctivegiven the marked differences in efficacy exhibited by individual bacterial strains across distinct health objectives (517)

Actual animal doses were 0.1 to 0.6 mg/kg

These are general examples only

doi: 10.7717/peerj.12510 76 ZhangJ

Amphiphilic macromolecules are attractive carriers since lipids form vesicles like biological membranes (Lasic and Papahadjopoulos 1995)

This is a mechanical and chemical irritation effect rather than a systemic toxicity