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Abstract Cardiovascular diseases (CVDs) and cognitive impairment syndromes, encompassing Alzheimers disease (AD) and vascular cognitive impairment (VCI), exhibit a robust epidemiological association

The small molecule ligand was processed using AutoDockTools 1.5.7 software, including adding hydrogen bonds and assigning proper torsion angles to chemical bonds, and then exported in PDBQT format

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Avoiding high-fat foods, dairy, and excessive fiber when diarrhea occursthen gradually reintroducing themhelps stabilize digestion

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The processes involve endoplasmic reticulum-associated degradation (ERAD) and are closely related to ubiquitination and proteasomal degradation functions of the UPS pathway [44,45,46]