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They are used primarily for weight management and the treatment of type 2 diabetes
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Figure 10 In addition to the sulfonamides, e.g., 40 and 41 , the spiro-oxindole dihydroquinazolinone derivative 42 was identified in the screening campaign and subsequently a large series of related analogues were made, e.g., by applying rapid MW-assisted reactions and thereafter examined as IRAP inhibitors in bioassays (Engen et al., 2020) (Figure 10)
In the last couple years, nonalcoholic fatty liver disease (NAFLD) has become the No
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