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High glutaminase expression in tumor tissues may be associated with poor prognosis [35, 36]

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Common side effects include nausea, vomiting, diarrhea, constipation, and reduced appetite, while serious risks include hypoglycemia, pancreatitis, and thyroid cancer in predisposed patients

For instance, Eli Lilly's obesity treatment tirzepatide activates both GLP-1 and GIP and has demonstrated greater weight loss effects than semaglutide

doi: 10.1210/en.2011-0281 99 WoolseySJBeatonMDMansellSELeon-PonteMYuJPinCLTironaRGet al

Dose-finding studies for CNS effects in humans are needed because extrapolation from rat doses is unreliable